Molecular tumor profile in FFPE tissue sample and liquid biopsy (prime DX® & prime DX® Liquid)
Genekor's prime DX® Combo enables the simultaneous testing of FFPE tissue and liquid biopsy samples, providing a comprehensive molecular profile by exploiting the advantages of both procedures.
Why Choose Simultaneous Tissue and Liquid Biopsy Testing?By integrating both approaches, clinicians gain a more comprehensive understanding of a patient’s tumor biology resulting in better-informed treatment decisions. Concurrent testing can lead to :
State-of-the-ArtState-Art Testing Platforms: Utilizing cutting-edge Next Generation Sequencing and both commercially available and proprietary bioinformatics tools, our simultaneous testing approach ensures precise, reliable, and comprehensive data.
Experienced Scientific Team: Our team of molecular scientists are experts in translating genomic data into actionable insights that guide and optimize personalized treatment approaches.
The new prime DX® test is based on advanced enrichment technology using hybridization probes of target genomic regions. Additionally, it uses molecular tracers (UMIs) for increased sensitivity in detecting somatic variants. This technology has shown high reproducibility, sensitivity and specificity and has therefore been adopted by leading oncology institutions worldwide.
The test uses the Oncology Multi-Gene Variant Assay (GenePlus), which is a qualitative in vitro diagnostic test (CE-IVD) that detects variants in 1021 tumor-associated genes and gene rearrangements/fusions in 38 genes.
It also analyzes biomarkers for immunotherapy response, including MSI (Microsatellite Instability), TMB (Tumor Mutational Burden), and HLA zygosity detection and biomarkers for chemotherapy response.
The MGI-DNBSEQ-G400 is a CE-IVD platform that enables the simultaneous processing of multiple samples with high sensitivity and specificity, delivering faster, reliable results at a lower cost.
In the new prime DX® test, the following predictive immunohistochemical markers can be added, performed at our pathology laboratory:
Which patients are eligible for the test?
All patients with a solid tumor are eligible.
How long does it take to get my results?
15 business days
What kind of sample and how much is required for the test?
For prime DX® Combo analysis, we need a paraffin block containing the tumour tissue. We need one paraffin block or four 3 µm paraffin sections: in positive charged slides (air dried at room temperature, not baked), placed on top of the slide, without folds and six unstained slides of 10μm.
Also, we need blood in special vials that you will receive from Genekor. (Cell-Free DNA BCT®(10ml) και Cell-Free RNA BCT®(10ml)).
Why is it necessary to analyse so many genes?
It is necessary to analyse so many genes because it helps to:
give you Quantity and Quality information
reduce time for the results
reduce costs for the test
A multi-gene panel results in the generation of a large amount of multi-level information of useful value greatly increasing the likelihood of finding a personalised cancer treatment plan for the patient.
Also, it has been shown that the more genes analysed, the more reliable the results for TMB.
Are there any special transportation conditions?
The blood sample (liquid biopsy) should be transported in conditions up to 20°C.
Why should I sign the consent form?
For the use of the patient’s genetic material for testing, ELOT EN ISO9001:2008 and ELOT EN ISO15189:2012 require the written consent of each patient.
Does any public/private insurance cover the test?
For information about the cost coverage of the test you should contact your insurance company.
How can I pay for the test?
Payment can be made by bank transfer or debit/credit card.
How can I send my sample?
To schedule pickup and return of your sample, please contact us.
How will I receive my results?
Your results are shared with your GP via email.
Our Customer Service Team is committed to answering your questions about the services offered by Genekor. If you are interested in any of the tests offered by Genekor, please contact us directly.
*To complete the test, you are required to complete and send the Consent form that you will find on the link below.
*For more information on scientific content please contact: scientific.support@genekor.com
*Download the promotional brochure here.