Com.pl.i.t DX® Colon

Com.pl.it DX® Colon

The Com.pl.it DX® Colon multi-gene test includes genes with mutations associated with colorectal cancer. The analysis of many of these genes is essential for the design of a personalised treatment plan for Colorectal Cancer patients.

How the Com.Pl.it DX® colon test helps in finding the right treatment

It determines the molecular profile (gene mutations) of the tumor and the interactions between genes in cases of multiple mutations
Identifies on-label drugs, which target either the mutated genes or the pathways in which they are involved
It identifies mutations associated with resistance to targeted therapies
Recommends off-label therapies or treatments in clinical trials based on the molecular profile of the tumor. This may be particularly important for patients where standard treatment has failed

Table of analysed genes

79 unique genes/73 genes full CDS analysed

ABL1	AKT1	ALK	APC	ARAF	ATM	BRAF	BRCA2	CCNE1
CDKN2A	CSF1R	CTNNB1	DDR2	DICER1	EGFR	EIF1AX	ERBB2	ERBB3
EZH1	EZH2	FBXW7	FGFR1	FGFR2	FGFR3	FLT3	FOXL2	GNA11
GNAS	HNF1A	HRAS	IDH1	IDH2	JAK2	JAK3	KDR	KEAP1
KRAS	MAP2K1	MDM2	MET	MLH1	MPL	MYC	NOTCH1	NPM1
NTRK1	NTRK2	NTRK3	PDGFRA	PIK3CA	POLE	PTEN	PTPN11	RAC1
RB1	RET	ROS1	SMAD4	SMARCB1	SMO	SOS1	SPOP	STK11
TERT	TP53	VHL

18 Gene fusions

ALK	BRAF	EGFR	ERG	FGFR2	FGFR3
MET	NRG1	NTRK1	NTRK2	NTRK3	PBX1
PPARG	PRKACA	RAF1	RET	ROS1	TFE3

Immunotherapy biomarkers

MSI

IHC biomarkers

HER2

Approved targeted therapies associated with multiple genes

KRAS, NRAS, KRAS G12C, BRAF V600E, NTRK1, NTRK2,NTRK3, RET rearrangements

Approved targeted treatments are also available for HER2 amplification
in patients whose tumors do not carry mutations in KRAS or NRAS.

Microsatellite instability (MSI) and mutations in the POLE gene (according to the NCCN Guidelines) are strong predictive biomarkers
for response to immunotherapy with immune checkpoint inhibitors.

Testing for POLE & PIK3CA in early-stage colorectal cancer

According to NCCN clinical guidelines, in patients with colorectal cancer, testing is recommended
not only for MSI but also for mutations in PIK3CA and POLE, as these alterations can guide personalized therapeutic decisions.

Frequently Asked Questions

What types of cancer does it cover?: It is designed for patients with colorectal cancer. It may also be used in other types of solid tumours, including those of unknown origin.
In how many days will the results be available?: Com.Pl.i.t DX® Colon results will be available in 10 business days from the day after sample receipt.
What kind of sample is required for Com.Pl.i.t DX® Colon?: For the analysis of Com.Pl.i.t.DX® colon we need the paraffin cube from the tumor or alternatively uncolored paraffin sections coated on slides (air-dried, not oven-dried). More specifically, we need 4 sections of 3μm and 6 sections of 10μm.
Are there any special transportation conditions?: The sample should be kept at room temperature (25 °C). During the summer season we recommend having an ice pack in the kit (The ice pack should not directly touch the samples and the documents)
Is the test covered by public/private insurance?: For information about the cost of the test you should contact your personal insurance or our company.
How can I make the payment for the test?: The Customer Service Department will provide you with a unique e-banking payment code, or payment can be made by card or bank transfer.
How can I send my sample?: Genekor is responsible for all necessary procedures for the receipt and return of your sample. To arrange sample collection and return, please contact us.
How will I get my results?: Your results will be shared with your doctor via a secure network and to you via e-mail with a secure unique code provided by customer service.
Why do I have to sign the consent form?: GeneKor Medical S.A. follows certified quality and information security systems, which require the written consent of each patient for the use of their genetic material for diagnostic testing.
In addition, written consent is mandatory according to data protection regulations.
You can view our certifications here.

How to order the test?

Our Customer Service Team is committed to answer your questions with regards to the services offered by Genekor. If you would like to order any of the tests that Genekor performs please contact us directly.

*To complete the test, you are required to complete and send the Consent form that you will find on the link below.

CONSENT FORM