{"id":9493,"date":"2024-03-27T08:22:36","date_gmt":"2024-03-27T08:22:36","guid":{"rendered":"https:\/\/genekor.com\/2024\/03\/27\/un-nou-studiu-microsatellite-instability-is-insufficiently-used-as-a-biomarker-for-lynch-syndrome-testing-in-clinical-practice\/"},"modified":"2024-04-19T07:04:53","modified_gmt":"2024-04-19T07:04:53","slug":"un-nou-studiu-microsatellite-instability-is-insufficiently-used-as-a-biomarker-for-lynch-syndrome-testing-in-clinical-practice","status":"publish","type":"post","link":"https:\/\/genekor.com\/ro\/2024\/03\/27\/un-nou-studiu-microsatellite-instability-is-insufficiently-used-as-a-biomarker-for-lynch-syndrome-testing-in-clinical-practice\/","title":{"rendered":"Un nou studiu: Microsatellite Instability Is Insufficiently Used as a Biomarker for Lynch Syndrome Testing in Clinical Practice"},"content":{"rendered":"\n

Studiul nostru recent „Instabilitatea microsatelitar\u0103 este insuficient utilizat\u0103 ca biomarker pentru testarea sindromului Lynch \u00een practica clinic\u0103” \u0219i-a propus s\u0103 determine c\u00e2t de des pacien\u021bii cu tumori cu MSI-High sunt supu\u0219i test\u0103rii genetice recomandate, de la care beneficiaz\u0103 pentru a \u0219ti ce avantaj vor avea din imunoterapie, precum \u0219i dintr-o posibil\u0103 asociere a bolii lor cu cancerul ereditar.<\/p>\n\n

Analiza instabilit\u0103\u021bii microsatelitare (MSI) este important\u0103 pentru identificarea pacien\u021bilor cu o probabilitate ridicat\u0103 de a r\u0103spunde la imunoterapie \u0219i este adesea asociat\u0103 cu prezen\u021ba muta\u021biilor mo\u0219tenite \u00een genele MMR (sindromul Lynch).<\/p>\n\n

Studiul nostru sugereaz\u0103 utilitatea acestei analize ca biomarker predictiv al r\u0103spunsului la imunoterapie \u00eentr-o gam\u0103 larg\u0103 de tipuri de cancer. Cu toate c\u0103 ghidurile interna\u021bionale recomand\u0103 testarea genetic\u0103 pentru muta\u021biile mo\u0219tenite \u00een genele MMR, indiferent de tipul de cancer sau de istoricul familial, la to\u021bi pacien\u021bii cu MSI, acest lucru nu pare s\u0103 fie aplicat \u00een practica clinic\u0103.<\/p>\n\n

Mai mult de jum\u0103tate dintre pacien\u021bii cu MSI-High, suspecta\u021bi de a avea muta\u021bii mo\u0219tenite, nu sunt supu\u0219i test\u0103rii genetice, rezult\u00e2nd subdiagnosticarea sindromului Lynch \u0219i a altor sindroame de cancer mo\u0219tenite.<\/p>\n\n

Pacien\u021bii cu MSI sunt un grup cu risc crescut pentru cancerul ereditar. Prin urmare, este important s\u0103 se creasc\u0103 con\u0219tientizarea valorii test\u0103rii genetice \u00een aceast\u0103 popula\u021bie.<\/p>\n\n

Citi\u021bi studiul aici: https:\/\/genekor.com\/wp-content\/uploads\/2024\/02\/po-8-e2300332.pdf<\/a><\/p>\n\n

<\/p>\n\n

\"\"<\/figure>\n","protected":false},"excerpt":{"rendered":"

Studiul nostru recent „Instabilitatea microsatelitar\u0103 este insuficient utilizat\u0103 ca biomarker pentru testarea sindromului Lynch \u00een practica clinic\u0103” \u0219i-a propus s\u0103 determine c\u00e2t de des pacien\u021bii cu tumori cu MSI-High sunt […]<\/p>\n","protected":false},"author":5,"featured_media":9475,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[33],"tags":[],"class_list":["post-9493","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-ro"],"acf":[],"yoast_head":"\nUn nou studiu: Microsatellite Instability Is Insufficiently Used as a Biomarker for Lynch Syndrome Testing in Clinical Practice - Genekor<\/title>\n<meta name=\"description\" content=\"Studiul nostru recent "Instabilitatea microsatelitar\u0103 este insuficient utilizat\u0103 ca biomarker pentru testarea sindromului Lynch \u00een practica 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