{"id":6007,"date":"2022-08-23T08:49:48","date_gmt":"2022-08-23T08:49:48","guid":{"rendered":"https:\/\/genekor.dermtherapy.gr\/2023\/12\/07\/proiectul-cureheart-o-echipa-de-experti-din-marea-britanie-sua-si-singapore-va-concepe-o-injectie-pentru-a-salva-mii-de-vieti-prin-rescrierea-adn-ului\/"},"modified":"2023-12-07T11:01:24","modified_gmt":"2023-12-07T11:01:24","slug":"proiectul-cureheart-o-echipa-de-experti-din-marea-britanie-sua-si-singapore-va-concepe-o-injectie-pentru-a-salva-mii-de-vieti-prin-rescrierea-adn-ului","status":"publish","type":"post","link":"https:\/\/genekor.com\/ro\/2022\/08\/23\/proiectul-cureheart-o-echipa-de-experti-din-marea-britanie-sua-si-singapore-va-concepe-o-injectie-pentru-a-salva-mii-de-vieti-prin-rescrierea-adn-ului\/","title":{"rendered":"Proiectul CureHeart \u2013 O echip\u0103 de exper\u021bi din Marea Britanie, SUA \u0219i Singapore va concepe o injec\u021bie pentru a salva mii de vie\u021bi prin rescrierea ADN-ului"},"content":{"rendered":"\n

Proiectul CureHeart<\/em><\/strong> – O echip\u0103 de exper\u021bi din Marea Britanie, SUA \u0219i Singapore va concepe o injec\u021bie pentru a salva mii de vie\u021bi prin rescrierea ADN-ului<\/em><\/p>\n\n

Cardiomiopatiile sunt \u201efoarte frecvente\u201d afecteaz\u0103 o persoan\u0103 din 250 din \u00eentreaga lume, a spus profesorul Hugh Watkins, de la Universitatea din Oxford \u0219i cercet\u0103torul principal al proiectului CureHeart.<\/p>\n\n

Oamenii de \u0219tiin\u021b\u0103 urmeaz\u0103 s\u0103 dezvolte primul remediu din lume pentru afec\u021biunile genetice ale inimii prin rescrierea ADN-ului \u00eentr-o mi\u0219care salutat\u0103 ca un \u201emoment definitoriu\u201d pentru medicina cardiovascular\u0103.<\/p>\n\n

Potrivit Guardian, echipa va folosi pentru prima dat\u0103 tehnici genetice de precizie \u00een inim\u0103, \u0219i anume tehnici de editare de baz\u0103 \u0219i primar\u0103, pentru a proiecta \u0219i testa primul remediu pentru bolile mo\u0219tenite ale mu\u0219chiului cardiac, cu scopul de a elimina genele defecte. Studiile pe animale au ar\u0103tat deja c\u0103 aceste tehnici func\u021bioneaz\u0103. Studiile pe animale au ar\u0103tat deja c\u0103 aceste tehnici func\u021bioneaz\u0103.<\/p>\n\n

\u201eAcesta este un moment decisiv pentru medicina cardiovascular\u0103\u201d, a spus profesorul Sir Nilesh Samani, directorul medical al BHF.<\/p>\n\n

Afec\u021biunile ereditare ale mu\u0219chiului cardiac sunt determinate de diferite anomalii ale inimii, dar pot provoca moartea subit\u0103 sau insuficien\u021b\u0103 cardiac\u0103 progresiv\u0103. Aproximativ 260.000 de oameni au aceast\u0103 afec\u021biune \u00een Marea Britanie, care poate provoca moarte subit\u0103 la orice v\u00e2rst\u0103.<\/p>\n\n

\u00cen fiecare s\u0103pt\u0103m\u00e2n\u0103 \u00een Marea Britanie, 12<\/strong> persoane cu v\u00e2rsta sub 35 de ani mor din cauza unei afec\u021biuni cardiace nediagnosticate, foarte adesea cauzat\u0103 de o boal\u0103 mo\u0219tenit\u0103 a mu\u0219chiului cardiac, cunoscut\u0103 \u0219i sub numele de cardiomiopatie genetic\u0103.<\/p>\n\n

To\u021bi cei cu cardiomiopatii genetice au un risc de 50\/50 de a transmite genele defecte fiec\u0103ruia dintre copiii lor \u0219i, adesea. De asemenea, mai mul\u021bi membri ai aceleia\u0219i familii care dezvolt\u0103 insuficien\u021b\u0103 cardiac\u0103, au nevoie de un transplant de inim\u0103 sau mor la o v\u00e2rst\u0103 fraged\u0103.<\/p>\n\n

Cardiomiopatiile sunt \u201efoarte frecvente\u201d afecteaz\u0103 o persoan\u0103 din 250 din \u00eentreaga lume, a spus profesorul Hugh Watkins, de la Universitatea din Oxford \u0219i cercet\u0103torul principal al proiectului CureHeart.<\/strong><\/p>\n\n

Oamenii de \u0219tiin\u021b\u0103 urmeaz\u0103 s\u0103 dezvolte primul remediu din lume pentru afec\u021biunile genetice ale inimii prin rescrierea ADN-ului \u00eentr-o mi\u0219care salutat\u0103 ca un \u201emoment definitoriu\u201d pentru medicina cardiovascular\u0103. Dup\u0103 ce au primit un grant de 30 de milioane de lire sterline de la British Heart Foundation, o echip\u0103 global\u0103 de exper\u021bi din Marea Britanie, SUA \u0219i Singapore \u00ee\u0219i unesc for\u021bele pentru a proiecta o injec\u021bie cu administrare \u00een bra\u021b pacien\u021bilor cu scopul de a salva mii de vie\u021bi.<\/p>\n\n

Christine Seidman, profesor de medicin\u0103 la Harvard Medical School din SUA \u0219i co-conduc\u0103tor al proiectului CureHeart, a spus c\u0103 ideea este de a \u201erepara inimile\u201d \u0219i reveni la o func\u021bie mai normal\u0103.<\/p>\n\n

Majoritatea muta\u021biilor pe care le g\u0103sim la pacien\u021bii no\u0219tri umani \u2013 \u0219i \u00een ultimul timp exist\u0103 un num\u0103r vast de muta\u021bii \u2013 toate vor modifica frecvent un singur element din codul ADN\u201d, a spus ea. \u201eAcest fapt a f\u0103cut posibil ca noi s\u0103 putem modifica o singur\u0103 liter\u0103 \u0219i rescrie codul, astfel \u00eenc\u00e2t acum s\u0103 avem o gen\u0103 normal\u0103, cu func\u021bie normal\u0103.”<\/p>\n\n

\u201ePutem fi capabili s\u0103 oferim aceste terapii \u00eenainte de apari\u021bia bolii acelor persoane despre care \u0219tim din testele genetice c\u0103 sunt expu\u0219i unui risc extraordinar de a dezvolta boala \u0219i a ajunge s\u0103 sufere de insuficien\u021b\u0103 cardiac\u0103. Niciodat\u0103 nu am putut s\u0103 vindec\u0103m \u0219i proiectul nostru este despre aceasta. \u0218tim c\u0103 putem face asta \u0219i noi a\u0219tept\u0103m cu ner\u0103bdare s\u0103 \u00eencepem.\u201d<\/p>\n\n

Sursa: Genetic heart conditions could be cured for first time in \u2018defining moment\u2019 | Heart disease | The Guardian<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Proiectul CureHeart – O echip\u0103 de exper\u021bi din Marea Britanie, SUA \u0219i Singapore va concepe o injec\u021bie pentru a salva mii de vie\u021bi prin rescrierea ADN-ului Cardiomiopatiile sunt \u201efoarte frecvente\u201d […]<\/p>\n","protected":false},"author":4,"featured_media":6008,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[33],"tags":[],"class_list":["post-6007","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-ro"],"acf":[],"yoast_head":"\nProiectul CureHeart - O echip\u0103 de exper\u021bi din Marea Britanie, SUA \u0219i Singapore va concepe o injec\u021bie pentru a salva mii de vie\u021bi prin rescrierea ADN-ului - Genekor<\/title>\n<meta name=\"description\" content=\"Oamenii de \u0219tiin\u021b\u0103 urmeaz\u0103 s\u0103 dezvolte primul remediu din lume pentru afec\u021biunile genetice ale inimii prin 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