{"id":5860,"date":"2020-06-18T07:24:00","date_gmt":"2020-06-18T07:24:00","guid":{"rendered":"https:\/\/genekor.dermtherapy.gr\/2023\/12\/06\/fda-a-aprobat-utilizarea-detectiei-tmb-ca-si-biomarker\/"},"modified":"2024-03-06T09:20:13","modified_gmt":"2024-03-06T09:20:13","slug":"fda-a-aprobat-utilizarea-detectiei-tmb-ca-si-biomarker","status":"publish","type":"post","link":"https:\/\/genekor.com\/ro\/2020\/06\/18\/fda-a-aprobat-utilizarea-detectiei-tmb-ca-si-biomarker\/","title":{"rendered":"FDA a aprobat utilizarea detectiei TMB ca si biomarker."},"content":{"rendered":"\n<p>FDA a aprobat utilizarea detectiei TMB ca si biomarker in alegerea tratamentului cu pembrolizumab(Keytruda\u2122) pentru adulti si copii in cazul tumorilor solide incurabile sau metastatice.<\/p>\n\n<p>Aceasta aprobare este bazata pe faza a doua a studiului clinic KEYNOTE-158, care a dezvaluit asocierea dintre TMB crescut si raspunsul la ORR cu inhibitor PD-1 la pacientii cu tumori complexe.<\/p>\n\n<p>TMB ajuta la identificarea numarului de mutatii prezente in genomul tumorii.<br\/>Tumorile cu o incarcatura mare tumorala(TMB crescut) pot avea un procentaj mai mare de neo-antigene si pot fi mai active din punct de vedere imunogenic comparativ cu tumorile cu o incarcatura mica tumorala.<\/p>\n\n<p><a rel=\"noreferrer noopener\" href=\"https:\/\/www.fda.gov\/drugs\/drug-approvals-and-databases\/fda-approves-pembrolizumab-adults-and-children-tmb-h-solid-tumors\" target=\"_blank\">Click here to see the FDA post<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>FDA a aprobat utilizarea detectiei TMB ca si biomarker in alegerea tratamentului cu pembrolizumab(Keytruda\u2122) pentru adulti si copii in cazul tumorilor solide incurabile sau metastatice. Aceasta aprobare este bazata pe [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3381,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[33],"tags":[],"class_list":["post-5860","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-ro"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.0 (Yoast SEO v24.0) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>FDA a aprobat utilizarea detectiei TMB ca si biomarker. - Genekor<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/genekor.com\/ro\/2020\/06\/18\/fda-a-aprobat-utilizarea-detectiei-tmb-ca-si-biomarker\/\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"FDA a aprobat utilizarea detectiei TMB ca si biomarker.\" \/>\n<meta property=\"og:description\" content=\"FDA a aprobat utilizarea detectiei TMB ca si biomarker in alegerea tratamentului cu pembrolizumab(Keytruda\u2122) pentru adulti si copii in cazul tumorilor solide incurabile sau metastatice. 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