{"id":22939,"date":"2026-09-10T07:08:36","date_gmt":"2026-09-10T07:08:36","guid":{"rendered":"https:\/\/genekor.com\/?p=22939"},"modified":"2026-09-10T07:26:01","modified_gmt":"2026-09-10T07:26:01","slug":"genomic-testing-early-stage-breast-cancer","status":"publish","type":"post","link":"https:\/\/genekor.com\/lv\/2026\/09\/10\/genomic-testing-early-stage-breast-cancer\/","title":{"rendered":"Genomisk\u0101 test\u0113\u0161ana pal\u012bdz pie\u0146emt prec\u012bz\u0101kus \u0101rst\u0113\u0161anas l\u0113mumus pacient\u0113m ar agr\u012bnu kr\u016bts v\u0113zi"},"content":{"rendered":"\n

P\u0113c kr\u016bts v\u0113\u017ea diagnozes noteik\u0161anas \u0101rsts kop\u0101 ar pacienti pie\u0146em vienu no svar\u012bg\u0101kajiem \u0101rst\u0113\u0161anas l\u0113mumiem \u2013 vai konkr\u0113taj\u0101 situ\u0101cij\u0101 \u0137\u012bmijterapija sniegs b\u016btisku ieguvumu. Latvij\u0101 \u012bstenota pilotprojekta<\/strong> \u201cJaunu molekul\u0101ri \u0123en\u0113tisko diagnostikas meto\u017eu ievie\u0161ana personaliz\u0113tai kr\u016bts v\u0113\u017ea pacientu \u0101rst\u0113\u0161anai Latvij\u0101\u201d (turpm\u0101k \u2013 Pilotprojekts)<\/strong><\/em> rezult\u0101ti liecina, ka genomisk\u0101 test\u0113\u0161ana var pal\u012bdz\u0113t daudz prec\u012bz\u0101k izv\u0113l\u0113ties piem\u0113rot\u0101ko \u0101rst\u0113\u0161anu pacient\u0113m ar agr\u012bnu kr\u016bts v\u0113zi.<\/strong><\/p>\n\n\n\n

Pilotprojekta laik\u0101 208 pacient\u0113m tika veikta genomisk\u0101 test\u0113\u0161ana, izmantojot Oncotype DX\u00ae testu<\/strong>. Rezult\u0101ti liecina, ka 76% pacientu p\u0113c test\u0113\u0161anas \u0137\u012bmijterapija netika iek\u013cauta \u0101rst\u0113\u0161anas pl\u0101n\u0101<\/strong>, savuk\u0101rt p\u0101r\u0113j\u0101m pacient\u0113m t\u0101 tika rekomend\u0113ta, balstoties uz test\u0113\u0161anas rezult\u0101tiem un citiem kl\u012bniskajiem r\u0101d\u012bt\u0101jiem.<\/p>\n\n\n\n

Latvij\u0101 katru gadu ar kr\u016bts v\u0113zi saslimst aptuveni 1200 sievie\u0161u<\/strong>. Starptautisk\u0101s vadl\u012bnijas noteiktai agr\u012bna kr\u016bts v\u0113\u017ea pacientu grupai iesaka izmantot papildu \u0123en\u0113tisko anal\u012bzi, lai izv\u0113rt\u0113tu iesp\u0113jamo ieguvumu no \u0137\u012bmijterapijas<\/strong>. Public\u0113tie starptautiskie dati, k\u0101 ar\u012b Latvij\u0101 \u012bstenot\u0101 Pilotprojekta rezult\u0101ti liecina, ka iev\u0113rojamai da\u013cai \u0161o pacientu \u0137\u012bmijterapija nesniedz b\u016btisku papildu ieguvumu<\/strong>.<\/p>\n\n\n\n

L\u012bdz \u0161im \u0101rst\u0113\u0161anas l\u0113mumi galvenok\u0101rt tika pie\u0146emti, balstoties uz audz\u0113ja izm\u0113ru, slim\u012bbas izplat\u012bbu un citiem kl\u012bniskajiem r\u0101d\u012bt\u0101jiem. Genomisk\u0101 test\u0113\u0161ana papildina \u0161o inform\u0101ciju, analiz\u0113jot audz\u0113ja biolo\u0123iju<\/strong> un pal\u012bdzot \u0101rstam pie\u0146emt individu\u0101li pamatot\u0101ku \u0101rst\u0113\u0161anas l\u0113mumu.<\/p>\n\n\n\n

Latvijas Onkologu \u0137\u012bmijterapeitu asoci\u0101cijas valdes priek\u0161s\u0113d\u0113t\u0101ja un Paula Stradi\u0146a Kl\u012bnisk\u0101s universit\u0101tes slimn\u012bcas Onkolo\u0123ijas kl\u012bnikas vad\u012bt\u0101ja Dr. Aija Geri\u0146a<\/strong> skaidro, ka:<\/p>\n\n\n\n

\n

“Prec\u012bzijas medic\u012bna \u0161odien ir neat\u0146emama m\u016bsdienu onkolo\u0123ijas sast\u0101vda\u013ca. Personaliz\u0113ta pieeja dod iesp\u0113ju pacientiem sa\u0146emt \u0101rst\u0113\u0161anu, kas sniegs visliel\u0101ko terapeitisko ieguvumu. Bez Genomisk\u0101s test\u0113\u0161anas, m\u016bsdien\u0101s nav iedom\u0101jama efekt\u012bga v\u0113\u017ea \u0101rst\u0113\u0161ana, kas sniedz b\u016btisku inform\u0101ciju par audz\u0113ja biolo\u0123iju, pal\u012bdzot gan daudz prec\u012bz\u0101k prognoz\u0113t slim\u012bbas gaitu, gan izv\u0113rt\u0113t \u0137\u012bmijterapijas ieguvumus, k\u0101 ar\u012b atbilst\u012bbu m\u0113r\u0137terapijai. Tas \u013cauj piem\u0113rot z\u0101les atbilsto\u0161i audz\u0113j\u0101 eso\u0161aj\u0101m v\u0113\u017ea \u0161\u016bnu \u0123en\u0113tisk\u0101m mut\u0101cij\u0101m un receptoriem, izvair\u012bties no toksiskas un prognoz\u0113jami neefkt\u012bgas terapijas.\u201d<\/em><\/p>\n<\/blockquote>\n\n\n\n

K\u0101 uzsver \u201cGeneKor\u201d SIA p\u0101rst\u0101ve Anitra Greivule<\/strong>, genomisk\u0101 test\u0113\u0161ana ir k\u013cuvusi par noz\u012bm\u012bgu instrumentu personaliz\u0113t\u0101 kr\u016bts v\u0113\u017ea \u0101rst\u0113\u0161an\u0101<\/strong>, jo t\u0101 pal\u012bdz \u0101rstam izv\u0113rt\u0113t iesp\u0113jamo ieguvumu no \u0137\u012bmijterapijas, analiz\u0113jot audz\u0113ja biolo\u0123iju. \u0160\u0101da pieeja ir iek\u013cauta starptautiskaj\u0101s kl\u012bniskaj\u0101s vadl\u012bnij\u0101s<\/strong> atbilsto\u0161\u0101m pacientu grup\u0101m.<\/p>\n\n\n\n

\n

\u201cPersonaliz\u0113t\u0101 medic\u012bna vairs nav n\u0101kotnes koncepts \u2013 t\u0101 jau \u0161odien ir m\u016bsdienu onkolo\u0123ijas neat\u0146emama sast\u0101vda\u013ca. Jo prec\u012bz\u0101ka ir inform\u0101cija par audz\u0113ju, jo pamatot\u0101ku \u0101rst\u0113\u0161anas l\u0113mumu \u0101rsts var pie\u0146emt kop\u0101 ar pacienti. \u0160\u0101da pieeja pal\u012bdz izv\u0113l\u0113ties \u0101rst\u0113\u0161anu, kas konkr\u0113tajam cilv\u0113kam sniegs visliel\u0101ko ieguvumu,\u201d uzsver Anitra Greivule.<\/p>\n<\/blockquote>\n\n\n\n

Neatkar\u012bga KPMG ekonomisk\u0101 anal\u012bze<\/strong> liecina, ka personaliz\u0113ta pieeja \u0101rst\u0113\u0161anai var sniegt ieguvumu gan pacient\u0113m, gan vesel\u012bbas apr\u016bpes sist\u0113mai. Samazinoties nevajadz\u012bgas \u0137\u012bmijterapijas gad\u012bjumu skaitam, iesp\u0113jams mazin\u0101t gan \u0101rst\u0113\u0161anas izmaksas, gan blak\u0146u rad\u012bto slogu. Anal\u012bz\u0113 secin\u0101ts, ka katrs genomiskaj\u0101 test\u0113\u0161an\u0101 ieguld\u012btais eiro ilgtermi\u0146\u0101 rada aptuveni 2,35 eiro ekonomisko ieguvumu<\/strong>.<\/p>\n\n\n\n

Atsauces redakcijai<\/strong><\/h2>\n\n\n\n

The earlier prospective validation of the 21-gene assay in TAILORx. Prospective Validation of the 21-Gene Expression Assay \u2013 NEJM<\/a> <\/p>\n\n\n\n

SPKC dati par kr\u016bts v\u0113\u017ea saslimst\u012bbu.<\/strong> SPKC \u2013 Newly registered cancer cases (ONKO030)<\/a><\/p>\n\n\n\n

NCCN Breast Cancer kl\u012bnisk\u0101s vadl\u012bnijas.<\/strong> NCCN Guidelines \u2013 Breast Cancer<\/a><\/p>\n\n\n\n

Public\u0113tie kl\u012bniskie dati par genomisko test\u0113\u0161anu.<\/strong><\/p>\n\n\n\n

KPMG ekonomisk\u0101 anal\u012bze par pilotprojektu.<\/strong> Report KPMG<\/a><\/p>\n\n\n\n

Sparano JA et al.<\/strong> Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer.<\/em> NEJM 2018 \u2014 TAILORx. TAILORx \u2013 New England Journal of Medicine<\/a><\/p>\n\n\n\n

Kalinsky K et al.<\/strong> 21-Gene Assay to Inform Chemotherapy Benefit in Node-Positive Breast Cancer.<\/em> NEJM 2021 \u2014 RxPONDER. RxPONDER \u2013 New England Journal of Medicine<\/a><\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

P\u0113c kr\u016bts v\u0113\u017ea diagnozes noteik\u0161anas \u0101rsts kop\u0101 ar pacienti pie\u0146em vienu no svar\u012bg\u0101kajiem \u0101rst\u0113\u0161anas l\u0113mumiem \u2013 vai konkr\u0113taj\u0101 situ\u0101cij\u0101 \u0137\u012bmijterapija sniegs b\u016btisku ieguvumu. Latvij\u0101 \u012bstenota pilotprojekta \u201cJaunu molekul\u0101ri \u0123en\u0113tisko diagnostikas […]<\/p>\n","protected":false},"author":9,"featured_media":23022,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[107],"tags":[],"class_list":["post-22939","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-lv"],"acf":[],"yoast_head":"\nGenomisk\u0101 test\u0113\u0161ana agr\u012bna kr\u016bts v\u0113\u017ea gad\u012bjum\u0101 | Genekor<\/title>\n<meta name=\"description\" content=\"Genomisk\u0101 test\u0113\u0161ana pal\u012bdz pacient\u0113m ar agr\u012bnu kr\u016bts v\u0113zi pie\u0146emt prec\u012bz\u0101kus \u0101rst\u0113\u0161anas l\u0113mumus un izv\u0113rt\u0113t iesp\u0113jamo ieguvumu no \u0137\u012bmijterapijas.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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