{"id":15928,"date":"2025-07-15T13:30:18","date_gmt":"2025-07-15T13:30:18","guid":{"rendered":"https:\/\/genekor.com\/?p=15928"},"modified":"2025-07-15T13:41:33","modified_gmt":"2025-07-15T13:41:33","slug":"nees-odigies-nccn-epikouriki-therapeia-prwimos-karkinos-enterou","status":"publish","type":"post","link":"https:\/\/genekor.com\/el\/2025\/07\/15\/nees-odigies-nccn-epikouriki-therapeia-prwimos-karkinos-enterou\/","title":{"rendered":"\u039d\u03ad\u03b5\u03c2 \u039a\u03b1\u03c4\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c1\u03b9\u03b5\u03c2 \u039f\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03c4\u03bf\u03c5 NCCN \u03b3\u03b9\u03b1 \u03a0\u03c1\u03ce\u03b9\u03bc\u03bf \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03a0\u03b1\u03c7\u03ad\u03bf\u03c2 \u0395\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5: \u039f \u03a1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03c9\u03bd \u0392\u03b9\u03bf\u03b4\u03b5\u03b9\u03ba\u03c4\u03ce\u03bd PIK3CA, POLE \u03ba\u03b1\u03b9 MSI \u03c3\u03c4\u03b7\u03bd \u039a\u03b1\u03b8\u03bf\u03b4\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u0395\u03c0\u03b9\u03ba\u03bf\u03c5\u03c1\u03b9\u03ba\u03ae\u03c2 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2"},"content":{"rendered":"\n<p>\u039f\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c7\u03b5\u03af\u03c2 \u03b5\u03be\u03b5\u03bb\u03af\u03be\u03b5\u03b9\u03c2 \u03c3\u03c4\u03b7 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03bc\u03b5\u03c4\u03b1\u03c3\u03c7\u03b7\u03bc\u03b1\u03c4\u03af\u03b6\u03bf\u03c5\u03bd \u03c1\u03b9\u03b6\u03b9\u03ba\u03ac \u03c4\u03bf\u03bd \u03c4\u03c1\u03cc\u03c0\u03bf \u03bc\u03b5 \u03c4\u03bf\u03bd \u03bf\u03c0\u03bf\u03af\u03bf \u03c0\u03c1\u03bf\u03c3\u03b5\u03b3\u03b3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae \u03c3\u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c0\u03b1\u03c7\u03ad\u03bf\u03c2 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5. \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03c4\u03b7\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2 <a href=\"https:\/\/mcusercontent.com\/84034efa59a7e43f306956007\/files\/94270538-3fd9-8b84-07d7-ce4aa8a388fe\/lindberg_et_al_2025_low_dose_aspirin_to_reduce_recurrence_rate_in_colorectal_cancer_patients_with_pi3k_pathway.pdf\">ALASCCA \u03c3\u03c4\u03bf ASCO GI 2025<\/a>, \u03ba\u03b1\u03b9 \u03b7 \u03b5\u03c0\u03b9\u03ba\u03b1\u03b9\u03c1\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd <strong>\u039a\u03b1\u03c4\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c1\u03b9\u03c9\u03bd \u039f\u03b4\u03b7\u03b3\u03b9\u03ce\u03bd \u03c4\u03bf\u03c5 NCCN \u03b3\u03b9\u03b1 \u03c4\u03bf 2025<\/strong> \u03b1\u03bd\u03b1\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03bf\u03c5\u03bd \u03c4\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03c9\u03bd <strong>\u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ce\u03bd \u03b4\u03b5\u03b9\u03ba\u03c4\u03ce\u03bd<\/strong>, \u03cc\u03c0\u03c9\u03c2 \u03bf\u03b9 <strong>\u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 PIK3CA<\/strong> \u03ba\u03b1\u03b9 <strong>POLE<\/strong>, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03b7 <strong>\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 MSI<\/strong>, \u03c3\u03c4\u03b7\u03bd <strong>\u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03af\u03ba\u03b5\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03ba\u03bf\u03c5\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2<\/strong> \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 <strong>\u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c0\u03b1\u03c7\u03ad\u03bf\u03c2 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5 \u03c3\u03c4\u03b1\u03b4\u03af\u03bf\u03c5 II\u2013III<\/strong> \u03c0\u03bf\u03c5 \u03c6\u03ad\u03c1\u03bf\u03c5\u03bd <strong>\u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c3\u03c4\u03b7\u03bd \u03bf\u03b4\u03cc PI3K<\/strong>. \u039f\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03c3\u03c4\u03bf <strong>37% \u03c4\u03c9\u03bd \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03b5\u03c7\u03cc\u03bd\u03c4\u03c9\u03bd<\/strong> \u03c3\u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7, \u03bc\u03b5 \u03ba\u03c5\u03c1\u03b9\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 <strong>\u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c3\u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf PIK3CA<\/strong>.<\/p>\n\n\n\n<p>\u0392\u03ac\u03c3\u03b5\u03b9 \u03b1\u03c5\u03c4\u03ce\u03bd \u03c4\u03c9\u03bd \u03b5\u03c5\u03c1\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd, \u03b7 <strong>\u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b3\u03b9\u03b1 PIK3CA<\/strong> \u03ad\u03c7\u03b5\u03b9 \u03c0\u03bb\u03ad\u03bf\u03bd \u03b5\u03bd\u03c3\u03c9\u03bc\u03b1\u03c4\u03c9\u03b8\u03b5\u03af \u03c3\u03c4\u03b9\u03c2 <strong>\u03bd\u03b5\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u039a\u03b1\u03c4\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c1\u03b9\u03b5\u03c2 \u039f\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03c4\u03bf\u03c5 NCCN<\/strong>, \u03bc\u03b5 \u03c3\u03cd\u03c3\u03c4\u03b1\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03b1\u03c3\u03c0\u03b9\u03c1\u03af\u03bd\u03b7\u03c2 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ac \u03ba\u03b1\u03b8\u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7 \u03c5\u03c0\u03bf\u03bf\u03bc\u03ac\u03b4\u03b1.<\/p>\n\n\n\n<p>\u03a0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1, \u03bf\u03b9 <strong>\u03b1\u03bd\u03b1\u03bd\u03b5\u03c9\u03bc\u03ad\u03bd\u03b5\u03c2 \u039f\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03c4\u03bf\u03c5 NCCN \u03b3\u03b9\u03b1 \u03c0\u03c1\u03ce\u03b9\u03bc\u03bf \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c7\u03ad\u03bf\u03c2 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5<\/strong> \u03b5\u03c0\u03b9\u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03bf\u03c5\u03bd \u03c0\u03bb\u03ad\u03bf\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 <strong>\u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 POLE<\/strong>, \u03bc\u03b1\u03b6\u03af \u03bc\u03b5 \u03c4\u03b7 <strong>\u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7\u03c2 DNA (dMMR)<\/strong> \u03ae \u03c4\u03bf <strong>\u03c8\u03b7\u03bb\u03cc \u03bc\u03b9\u03ba\u03c1\u03bf\u03b4\u03bf\u03c1\u03c5\u03c6\u03bf\u03c1\u03b9\u03ba\u03cc \u03c6\u03bf\u03c1\u03c4\u03af\u03bf (MSI-H)<\/strong>, \u03c9\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 <strong>\u03b5\u03c5\u03bd\u03bf\u03ca\u03ba\u03ae\u03c2 \u03c0\u03c1\u03cc\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2<\/strong>. <\/p>\n\n\n\n<p>\u039f\u03b9 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 <strong>POLE<\/strong> \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf <strong>2,09% \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03c3\u03c4\u03b1\u03b4\u03af\u03bf\u03c5 II<\/strong> \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf <strong>0,66% \u03c3\u03c4\u03b1\u03b4\u03af\u03bf\u03c5 III<\/strong> \u03ba\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 <strong>\u03b1\u03bc\u03bf\u03b9\u03b2\u03b1\u03af\u03b1 \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2<\/strong> \u03bc\u03b5 \u03c4\u03b7\u03bd <strong>\u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7\u03c2 DNA<\/strong>. (<a href=\"https:\/\/mcusercontent.com\/84034efa59a7e43f306956007\/files\/58c37fdc-dfe4-307e-1f4b-2dc01f0d752e\/domingo2016.pdf\">\u0394\u03b9\u03b1\u03b2\u03ac\u03c3\u03c4\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1)<\/a>. \u03a0\u03b1\u03c1\u03cc\u03c4\u03b9 \u03c4\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1, \u03b7 \u03b5\u03bd\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ce\u03bd \u03c4\u03c9\u03bd \u03b2\u03b9\u03bf\u03b4\u03b5\u03b9\u03ba\u03c4\u03ce\u03bd \u03c3\u03c4\u03bf\u03c5\u03c2 <strong>\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b1\u03bb\u03b3\u03cc\u03c1\u03b9\u03b8\u03bc\u03bf\u03c5\u03c2<\/strong> \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd <strong>\u03b1\u03ba\u03c1\u03b9\u03b2\u03ad\u03c3\u03c4\u03b5\u03c1\u03b7 \u03c3\u03c4\u03b1\u03b4\u03b9\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5<\/strong> \u03ba\u03b1\u03b9 \u03c4\u03b7 <strong>\u03b4\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03c6\u03c5\u03b3\u03ae \u03c5\u03c0\u03b5\u03c1\u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7\u03c2 \u03b3\u03b9\u03b1 \u03b5\u03c0\u03b9\u03ba\u03bf\u03c5\u03c1\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1<\/strong>.<\/p>\n\n\n\n<p>\u0391\u03bd \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03c4\u03c1\u03ad\u03c7\u03bf\u03c5\u03c3\u03b5\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03c4\u03bf\u03c5 NCCN \u03b4\u03b5\u03bd \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03b1\u03ba\u03cc\u03bc\u03b7 \u03c4\u03b7 <strong>\u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03c7\u03c1\u03ae\u03c3\u03b7 \u03b5\u03ba\u03c4\u03b5\u03c4\u03b1\u03bc\u03ad\u03bd\u03c9\u03bd \u03c0\u03bf\u03bb\u03c5\u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03ce\u03bd \u03b1\u03bd\u03b1\u03bb\u03cd\u03c3\u03b5\u03c9\u03bd<\/strong> \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03bb\u03ae\u03c8\u03b7 \u03b1\u03c0\u03bf\u03c6\u03ac\u03c3\u03b5\u03c9\u03bd \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03ba\u03bf\u03c5\u03c1\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03ce\u03b9\u03bc\u03bf\u03c5 CRC, \u03c4\u03b1 \u03bd\u03ad\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 <strong>\u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03bf\u03b9 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03bf\u03af \u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2<\/strong> \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03ba\u03b1\u03b8\u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd <strong>\u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03af\u03ba\u03b5\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2<\/strong>.<\/p>\n\n\n\n<p>\u03a4\u03bf <strong>Com.pl.i.t DX Colon panel<\/strong>, \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03ae\u03b4\u03b7 \u03c3\u03c4\u03bf\u03bd <strong>\u03bc\u03b5\u03c4\u03b1\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c0\u03b1\u03c7\u03ad\u03bf\u03c2 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5 (mCRC)<\/strong>, \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7 \u03c4\u03c9\u03bd <strong>PIK3CA, POLE \u03ba\u03b1\u03b9 MSI<\/strong>, \u03c0\u03b1\u03c1\u03ad\u03c7\u03bf\u03bd\u03c4\u03b1\u03c2 \u03ad\u03bd\u03b1 <strong>\u03bf\u03bb\u03bf\u03ba\u03bb\u03b7\u03c1\u03c9\u03bc\u03ad\u03bd\u03bf \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc \u03c0\u03c1\u03bf\u03c6\u03af\u03bb<\/strong> \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b5\u03c5\u03b8\u03c5\u03b3\u03c1\u03b1\u03bc\u03bc\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b9\u03c2 <strong>\u03bd\u03b5\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b5\u03be\u03b5\u03bb\u03af\u03be\u03b5\u03b9\u03c2<\/strong>.<\/p>\n\n\n\n<p>\u039c\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ac \u03c4\u03b1 \u03bd\u03ad\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1, \u03c4\u03bf <strong>Com.pl.i.t DX Colon<\/strong> \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03b5\u03b9 \u03ad\u03bd\u03b1 <strong>\u03c0\u03bf\u03bb\u03cd\u03c4\u03b9\u03bc\u03bf \u03b5\u03c1\u03b3\u03b1\u03bb\u03b5\u03af\u03bf<\/strong> \u03b3\u03b9\u03b1 \u03c4\u03b7 <strong>\u03bb\u03ae\u03c8\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ce\u03bd \u03b1\u03c0\u03bf\u03c6\u03ac\u03c3\u03b5\u03c9\u03bd<\/strong> \u03c3\u03c4\u03bf\u03bd <strong>\u03c0\u03c1\u03ce\u03b9\u03bc\u03bf \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c0\u03b1\u03c7\u03ad\u03bf\u03c2 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5 (\u03c3\u03c4\u03ac\u03b4\u03b9\u03bf II\u2013III)<\/strong>, \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03cc\u03c3\u03bf: \u03c4\u03b7\u03bd <strong>\u03b1\u03c0\u03bf\u03c6\u03c5\u03b3\u03ae \u03c5\u03c0\u03b5\u03c1\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2<\/strong> (\u03c0.\u03c7. \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03bc\u03b5 <strong>POLE \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2<\/strong> \u03ae <strong>MSI-H<\/strong>) , \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd <strong>\u03b5\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2<\/strong> (\u03c0.\u03c7. \u03c7\u03c1\u03ae\u03c3\u03b7 \u03b1\u03c3\u03c0\u03b9\u03c1\u03af\u03bd\u03b7\u03c2 \u03c3\u03b5 \u03cc\u03b3\u03ba\u03bf\u03c5\u03c2 \u03bc\u03b5 <strong>\u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 PIK3CA<\/strong>). <\/p>\n\n\n\n<p>\u03a4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b5\u03c2 \u039f\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 NCCN (\u0399\u03bf\u03cd\u03bb\u03b9\u03bf\u03c2 2025): &nbsp;<a href=\"https:\/\/genekor.com\/wp-content\/uploads\/2025\/07\/NCCN_Guidelines.pdf\">https:\/\/genekor.com\/wp-content\/uploads\/2025\/07\/NCCN_Guidelines.pdf<\/a><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u039f\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c7\u03b5\u03af\u03c2 \u03b5\u03be\u03b5\u03bb\u03af\u03be\u03b5\u03b9\u03c2 \u03c3\u03c4\u03b7 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03bc\u03b5\u03c4\u03b1\u03c3\u03c7\u03b7\u03bc\u03b1\u03c4\u03af\u03b6\u03bf\u03c5\u03bd \u03c1\u03b9\u03b6\u03b9\u03ba\u03ac \u03c4\u03bf\u03bd \u03c4\u03c1\u03cc\u03c0\u03bf \u03bc\u03b5 \u03c4\u03bf\u03bd \u03bf\u03c0\u03bf\u03af\u03bf \u03c0\u03c1\u03bf\u03c3\u03b5\u03b3\u03b3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae \u03c3\u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c0\u03b1\u03c7\u03ad\u03bf\u03c2 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5. \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03c4\u03b7\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2 ALASCCA \u03c3\u03c4\u03bf ASCO [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":16452,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-15928","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-1"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.0 (Yoast SEO v24.0) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u039d\u03ad\u03b5\u03c2 \u039a\u03b1\u03c4\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c1\u03b9\u03b5\u03c2 \u039f\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03c4\u03bf\u03c5 NCCN \u03b3\u03b9\u03b1 \u03a0\u03c1\u03ce\u03b9\u03bc\u03bf \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03a0\u03b1\u03c7\u03ad\u03bf\u03c2 \u0395\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5: \u039f \u03a1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03c9\u03bd \u0392\u03b9\u03bf\u03b4\u03b5\u03b9\u03ba\u03c4\u03ce\u03bd PIK3CA, POLE \u03ba\u03b1\u03b9 MSI \u03c3\u03c4\u03b7\u03bd \u039a\u03b1\u03b8\u03bf\u03b4\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u0395\u03c0\u03b9\u03ba\u03bf\u03c5\u03c1\u03b9\u03ba\u03ae\u03c2 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 - Genekor<\/title>\n<meta name=\"description\" content=\"\u039f\u03b9 \u03bd\u03ad\u03b5\u03c2 \u039f\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 NCCN 2025 \u03b5\u03bd\u03c3\u03c9\u03bc\u03b1\u03c4\u03ce\u03bd\u03bf\u03c5\u03bd PIK3CA, POLE \u03ba\u03b1\u03b9 MSI \u03c9\u03c2 \u03b2\u03b9\u03bf\u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03ba\u03b1\u03b8\u03bf\u03b4\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03ba\u03bf\u03c5\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03c3\u03c4\u03bf\u03bd \u03c0\u03c1\u03ce\u03b9\u03bc\u03bf CRC.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/genekor.com\/el\/2025\/07\/15\/nees-odigies-nccn-epikouriki-therapeia-prwimos-karkinos-enterou\/\" \/>\n<meta property=\"og:locale\" content=\"el_GR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u039d\u03ad\u03b5\u03c2 \u039a\u03b1\u03c4\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c1\u03b9\u03b5\u03c2 \u039f\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03c4\u03bf\u03c5 NCCN \u03b3\u03b9\u03b1 \u03a0\u03c1\u03ce\u03b9\u03bc\u03bf \u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03a0\u03b1\u03c7\u03ad\u03bf\u03c2 \u0395\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5: \u039f \u03a1\u03cc\u03bb\u03bf\u03c2 \u03c4\u03c9\u03bd \u0392\u03b9\u03bf\u03b4\u03b5\u03b9\u03ba\u03c4\u03ce\u03bd PIK3CA, POLE \u03ba\u03b1\u03b9 MSI \u03c3\u03c4\u03b7\u03bd \u039a\u03b1\u03b8\u03bf\u03b4\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u0395\u03c0\u03b9\u03ba\u03bf\u03c5\u03c1\u03b9\u03ba\u03ae\u03c2 \u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2\" \/>\n<meta property=\"og:description\" content=\"\u039f\u03b9 \u03bd\u03ad\u03b5\u03c2 \u039f\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 NCCN 2025 \u03b5\u03bd\u03c3\u03c9\u03bc\u03b1\u03c4\u03ce\u03bd\u03bf\u03c5\u03bd PIK3CA, POLE \u03ba\u03b1\u03b9 MSI \u03c9\u03c2 \u03b2\u03b9\u03bf\u03b4\u03b5\u03af\u03ba\u03c4\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03ba\u03b1\u03b8\u03bf\u03b4\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03ba\u03bf\u03c5\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03c3\u03c4\u03bf\u03bd \u03c0\u03c1\u03ce\u03b9\u03bc\u03bf CRC.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/genekor.com\/el\/2025\/07\/15\/nees-odigies-nccn-epikouriki-therapeia-prwimos-karkinos-enterou\/\" \/>\n<meta property=\"og:site_name\" content=\"Genekor\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/genekorbiotechnology\/\" \/>\n<meta property=\"article:published_time\" content=\"2025-07-15T13:30:18+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-07-15T13:41:33+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/genekor.com\/wp-content\/uploads\/2025\/07\/f1c8313f-2a68-371b-9b88-90d6e6e6f965.png\" \/>\n\t<meta property=\"og:image:width\" content=\"700\" \/>\n\t<meta property=\"og:image:height\" content=\"394\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Ioanna Potska\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u03a3\u03c5\u03bd\u03c4\u03ac\u03c7\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc\" \/>\n\t<meta name=\"twitter:data1\" content=\"Ioanna Potska\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u0395\u03ba\u03c4\u03b9\u03bc\u03ce\u03bc\u03b5\u03bd\u03bf\u03c2 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 \u03bb\u03b5\u03c0\u03c4\u03ac\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/genekor.com\/el\/2025\/07\/15\/nees-odigies-nccn-epikouriki-therapeia-prwimos-karkinos-enterou\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/genekor.com\/el\/2025\/07\/15\/nees-odigies-nccn-epikouriki-therapeia-prwimos-karkinos-enterou\/\"},\"author\":{\"name\":\"Ioanna Potska\",\"@id\":\"https:\/\/genekor.com\/el\/#\/schema\/person\/d6c43cd4b4be66582d408967392cbcbd\"},\"headline\":\"\u039d\u03ad\u03b5\u03c2 \u039a\u03b1\u03c4\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c1\u03b9\u03b5\u03c2 \u039f\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03c4\u03bf\u03c5 NCCN \u03b3\u03b9\u03b1 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