{"id":14619,"date":"2025-01-28T11:19:04","date_gmt":"2025-01-28T11:19:04","guid":{"rendered":"https:\/\/genekor.com\/?p=14619"},"modified":"2025-02-11T11:47:42","modified_gmt":"2025-02-11T11:47:42","slug":"tumor-profiling-tests-to-guide-adjuvant-chemotherapy-decision-in-early-breast-cancer","status":"publish","type":"post","link":"https:\/\/genekor.com\/el\/2025\/01\/28\/tumor-profiling-tests-to-guide-adjuvant-chemotherapy-decision-in-early-breast-cancer\/","title":{"rendered":"Tumor profiling tests to guide adjuvant chemotherapy decision in early breast cancer"},"content":{"rendered":"\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-nice-diagnostics-guidance-evaluation-of-effectiveness-and-efficiency\"><strong>NICE diagnostics guidance \u2013 evaluation of effectiveness and efficiency<\/strong><\/h3>\n\n\n\n<p><strong><br><\/strong>The NICE (National Institute for Health and Care Excellence) diagnostics guidance DG58 gives<br><strong>evidence-based recommendations to guide treatment decisions <\/strong>and evaluate the<strong> efficiency<br>and cost-effectiveness <\/strong>of products and services in the health system of England and Wales.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-use-of-multigene-assays-mgas-for-tumour-profiling\"><strong>Use of multigene assays (MGAs) for tumour profiling<\/strong><\/h3>\n\n\n\n<p><strong><br><\/strong>Tumour profiling by MGAs could be used to guide decisions on adjuvant chemotherapy by<br>identifying patients who:<\/p>\n\n\n\n<p><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>may <strong>not benefit from adjuvant chemotherapy and avoid unnecessary treatment.<\/strong><\/li>\n\n\n\n<li>who would <strong>actually benefit from chemotherapy<\/strong>, although they have a <strong>low risk<\/strong> of disease recurrence <strong>due to clinical factors<\/strong>.<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"976\" height=\"394\" src=\"https:\/\/genekor.com\/wp-content\/uploads\/2025\/01\/image.png\" alt=\"\" class=\"wp-image-14915\" srcset=\"https:\/\/genekor.com\/wp-content\/uploads\/2025\/01\/image.png 976w, https:\/\/genekor.com\/wp-content\/uploads\/2025\/01\/image-300x121.png 300w, https:\/\/genekor.com\/wp-content\/uploads\/2025\/01\/image-768x310.png 768w\" sizes=\"auto, (max-width: 976px) 100vw, 976px\" \/><\/figure>\n\n\n\n<p>This summary of NICE diagnostics guidance \u2018Tumour profiling tests to guide adjuvant chemotherapy decisions in early breast cancer\u2019 (DG58) is promotional material. NICE has checked the accuracy of the content in this leaflet specifically relating to the NICE guidance. NICE is independent of any company or product advertised.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-economic-value-of-multigene-assays-mgas\">Economic value of multigene assays MGAs<\/h2>\n\n\n\n<p><br>Economic modelling suggests that <strong>Oncotype DX\u00ae<\/strong>, EndoPredict\u00ae and Prosigna\u00ae are <strong>cost-effective <\/strong>compared with standard care in postmenopausal women. All 3 tests had<strong> ICERs &lt; \u00a3 20,000<\/strong> <strong>per QALY <\/strong>gained when compared to not using tumour profiling tests.<\/p>\n\n\n\n<p>MammaPrint\u00ae is likely to be less clinically effective and costs more than standard care.<br><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-cost-effectiveness-of-oncotype-dx\">Cost-effectiveness of Oncotype DX\u00ae<\/h3>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"961\" height=\"237\" src=\"https:\/\/genekor.com\/wp-content\/uploads\/2025\/01\/image-1.png\" alt=\"\" class=\"wp-image-14922\" srcset=\"https:\/\/genekor.com\/wp-content\/uploads\/2025\/01\/image-1.png 961w, https:\/\/genekor.com\/wp-content\/uploads\/2025\/01\/image-1-300x74.png 300w, https:\/\/genekor.com\/wp-content\/uploads\/2025\/01\/image-1-768x189.png 768w\" sizes=\"auto, (max-width: 961px) 100vw, 961px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-impact-on-chemotherapy-services\">Impact on Chemotherapy Services<\/h3>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"985\" height=\"456\" src=\"https:\/\/genekor.com\/wp-content\/uploads\/2025\/01\/image-2.png\" alt=\"\" class=\"wp-image-14929\" srcset=\"https:\/\/genekor.com\/wp-content\/uploads\/2025\/01\/image-2.png 985w, https:\/\/genekor.com\/wp-content\/uploads\/2025\/01\/image-2-300x139.png 300w, https:\/\/genekor.com\/wp-content\/uploads\/2025\/01\/image-2-768x356.png 768w\" sizes=\"auto, (max-width: 985px) 100vw, 985px\" \/><\/figure>\n\n\n\n<p>ICER = incremental cost-effectiveness ratio<br>QALY = quality adjusted life year<br>EAG = external assessment group<br>EXS15031_1024_EN_INT<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>NICE diagnostics guidance \u2013 evaluation of effectiveness and efficiency The NICE (National Institute for Health and Care Excellence) diagnostics guidance DG58 givesevidence-based recommendations to guide treatment decisions and evaluate the [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":15016,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[68],"tags":[],"class_list":["post-14619","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.0 (Yoast SEO v24.0) - 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