{"id":15028,"date":"2025-01-28T11:19:04","date_gmt":"2025-01-28T11:19:04","guid":{"rendered":"https:\/\/genekor.com\/2025\/01\/28\/tumor-profiling-tests-to-guide-adjuvant-chemotherapy-decision-in-early-breast-cancer\/"},"modified":"2025-02-12T12:16:33","modified_gmt":"2025-02-12T12:16:33","slug":"tumor-profiling-tests-to-guide-adjuvant-chemotherapy-decision-in-early-breast-cancer","status":"publish","type":"post","link":"https:\/\/genekor.com\/cs\/2025\/01\/28\/tumor-profiling-tests-to-guide-adjuvant-chemotherapy-decision-in-early-breast-cancer\/","title":{"rendered":"Pou\u017eit\u00ed genomick\u00fdch test\u016f pro rozhodov\u00e1n\u00ed o adjuvantn\u00ed chemoterapii u \u010dasn\u00e9ho karcinomu prsu"},"content":{"rendered":"\n
<\/p>\n\n\n\n
Hodnocen\u00ed \u00fa\u010dinnosti a efektivity v r\u00e1mci diagnostick\u00fdch pokyn\u016f NICE<\/strong><\/h3>\n\n\n\n
<\/strong>Pokyny N\u00e1rodn\u00edho \u00fastavu pro zdrav\u00ed a klinickou kvalitu (National Institute for Health and Care Excellence, NICE) pro diagnostiku DG58 poskytuj\u00ed doporu\u010den\u00ed zalo\u017een\u00e1 na v\u011bdeck\u00fdch d\u016fkazech, kter\u00e1 vedou k rozhodnut\u00ed o l\u00e9\u010db\u011b<\/strong> a hodnocen\u00ed efektivity a n\u00e1kladovosti<\/strong> produkt\u016f a slu\u017eeb ve zdravotnick\u00e9m syst\u00e9mu Anglie a Walesu.<\/p>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n\n\n\n
Pou\u017eit\u00ed multigenov\u00fdch test\u016f (MGA) k profilov\u00e1n\u00ed n\u00e1dor\u016f<\/strong><\/strong><\/h3>\n\n\n\n
<\/strong>Testov\u00e1n\u00ed multigenov\u00fdmi testy (multigene assays, MGA) k profilov\u00e1n\u00ed n\u00e1dor\u016f by mohlo pomoci p\u0159i rozhodov\u00e1n\u00ed o adjuvantn\u00ed chemoterapii t\u00edm, \u017ee identifikuje pacienty, kte\u0159\u00ed:<\/p>\n\n\n\n
\n
nemus\u00ed m\u00edt z adjuvantn\u00ed chemoterapie \u017e\u00e1dn\u00fd prosp\u011bch<\/strong> a mohou se tak vyhnout nadbyte\u010dn\u00e9 l\u00e9\u010db\u011b<\/strong>,<\/li>\n\n\n\n
by naopak z chemoterapie mohli skute\u010dn\u011b profitovat<\/strong>, p\u0159esto\u017ee maj\u00ed na z\u00e1klad\u011b klinick\u00fdch faktor\u016f n\u00edzk\u00e9 riziko<\/strong> recidivy.<\/li>\n<\/ul>\n\n\n\n
<\/p>\n\n\n\n<\/figure>\n\n\n\n
<\/p>\n\n\n\n
Toto shrnut\u00ed pokyn\u016f NICE pro diagnostiku \u201ePou\u017eit\u00ed genomick\u00fdch test\u016f pro rozhodov\u00e1n\u00ed o adjuvantn\u00ed chemoterapii u \u010dasn\u00e9ho karcinomu prsu\u201c (DG58) slou\u017e\u00ed jako propaga\u010dn\u00ed materi\u00e1l. NICE ov\u011b\u0159il spr\u00e1vnost obsahu t\u011bchto tvrzen\u00ed, kter\u00fd se vztahuje konkr\u00e9tn\u011b k pokyn\u016fm NICE. \u00dastav NICE je nez\u00e1visl\u00fd na jak\u00e9koli spole\u010dnosti nebo produktu, kter\u00fd je zde inzerov\u00e1n.<\/em><\/p>\n\n\n\n
Ekonomick\u00e9 modelov\u00e1n\u00ed nazna\u010duje, \u017ee testy Oncotype DX\u00ae<\/strong>, EndoPredict\u00ae a Prosigna\u00ae jsou n\u00e1kladov\u011b efektivn\u00ed<\/strong> ve srovn\u00e1n\u00ed se standardn\u00ed p\u00e9\u010d\u00ed u postmenopauz\u00e1ln\u00edch \u017een. V\u0161echny 3 testy m\u011bly ICER < 20 000 liber na z\u00edskanou hodnotu QALY<\/strong> ve srovn\u00e1n\u00ed s neprov\u00e1d\u011bn\u00edm t\u011bchto genomick\u00fdch test\u016f.<\/p>\n\n\n\n
MammaPrint\u00ae pravd\u011bpodobn\u011b vykazuje ni\u017e\u0161\u00ed klinickou \u00fa\u010dinnost a je dra\u017e\u0161\u00ed ne\u017e standardn\u00ed p\u00e9\u010de.<\/p>\n\n\n\n
<\/p>\n\n\n\n
Ekonomick\u00e1 efektivnost testu Oncotype DX\u00ae<\/strong><\/h3>\n\n\n\n
3.18<\/p>\n\n\n\n
V\u00fdbor NICE dosp\u011bl k z\u00e1v\u011bru, \u017ee Oncotype DX\u00ae <\/strong>je pravd\u011bpodobn\u011b n\u00e1kladov\u011b efektivn\u00ed<\/strong> zp\u016fsob vyu\u017eit\u00ed zdroj\u016f NHS, pokud se pou\u017e\u00edv\u00e1 p\u0159i rozhodov\u00e1n\u00ed o pod\u00e1n\u00ed adjuvantn\u00ed chemoterapie<\/strong> u postmenopauz\u00e1ln\u00edch \u017een.<\/p>\n\n\n\n
Dopad na efektivitu chemoterapie<\/strong><\/h3>\n\n\n\n
3.21<\/p>\n\n\n\n
EndoPredict\u00ae, Oncotype DX\u00ae<\/strong> a Prosigna\u00ae jsou pravd\u011bpodobn\u011b n\u00e1kladov\u011b efektivn\u00ed v porovn\u00e1n\u00ed s nepou\u017e\u00edv\u00e1n\u00edm t\u011bchto genomick\u00fdch test\u016f.<\/p>\n\n\n\n
3.21<\/p>\n\n\n\n
Podle odhad\u016f EAG na z\u00e1klad\u011b ekonomick\u00e9ho modelu by pou\u017eit\u00ed testu Oncotype DX\u00ae<\/strong> vedlo k tomu, \u017ee 594 \u017een z 1 000 testovan\u00fdch nebude muset podstoupit chemoterapii<\/strong>. Testy EndoPredict\u00ae a Prosigna\u00ae vykazovaly toto sn\u00ed\u017een\u00ed p\u0159ibli\u017en\u011b o 40 \u017een.<\/p>\n\n\n\n
ICER = pom\u011br inkrement\u00e1ln\u00edch n\u00e1klad\u016f a p\u0159\u00ednos\u016f<\/strong> QALY = rok \u017eivota v pln\u00e9 kvalit\u011b<\/strong> EAG = extern\u00ed hodnot\u00edc\u00ed skupina<\/strong> EXS15031_1024_EN_INT<\/p>\n\n\n\n
Hodnocen\u00ed \u00fa\u010dinnosti a efektivity v r\u00e1mci diagnostick\u00fdch pokyn\u016f NICE Pokyny N\u00e1rodn\u00edho \u00fastavu pro zdrav\u00ed a klinickou kvalitu (National Institute for Health and Care Excellence, NICE) pro diagnostiku DG58 poskytuj\u00ed doporu\u010den\u00ed […]<\/p>\n","protected":false},"author":5,"featured_media":15017,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[123],"tags":[],"class_list":["post-15028","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-cs"],"acf":[],"yoast_head":"\n
Pou\u017eit\u00ed genomick\u00fdch test\u016f pro rozhodov\u00e1n\u00ed o adjuvantn\u00ed chemoterapii u \u010dasn\u00e9ho karcinomu prsu - Genekor<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/genekor.com\/cs\/2025\/01\/28\/tumor-profiling-tests-to-guide-adjuvant-chemotherapy-decision-in-early-breast-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"cs_CZ\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pou\u017eit\u00ed genomick\u00fdch test\u016f pro rozhodov\u00e1n\u00ed o adjuvantn\u00ed chemoterapii u \u010dasn\u00e9ho karcinomu prsu\" \/>\n<meta property=\"og:description\" content=\"Hodnocen\u00ed \u00fa\u010dinnosti a efektivity v r\u00e1mci diagnostick\u00fdch pokyn\u016f NICE Pokyny N\u00e1rodn\u00edho \u00fastavu pro zdrav\u00ed a klinickou kvalitu (National Institute for Health and Care Excellence, NICE) pro diagnostiku DG58 poskytuj\u00ed doporu\u010den\u00ed […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/genekor.com\/cs\/2025\/01\/28\/tumor-profiling-tests-to-guide-adjuvant-chemotherapy-decision-in-early-breast-cancer\/\" \/>\n<meta property=\"og:site_name\" content=\"Genekor\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/genekorbiotechnology\/\" \/>\n<meta property=\"article:published_time\" content=\"2025-01-28T11:19:04+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-02-12T12:16:33+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/genekor.com\/wp-content\/uploads\/2025\/01\/logo-landscape-800x281-800x281-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"800\" \/>\n\t<meta property=\"og:image:height\" content=\"281\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Ioanna Potska\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Napsal(a)\" \/>\n\t<meta name=\"twitter:data1\" content=\"Ioanna Potska\" \/>\n\t<meta name=\"twitter:label2\" content=\"Odhadovan\u00e1 doba \u010dten\u00ed\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuty\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/genekor.com\/cs\/2025\/01\/28\/tumor-profiling-tests-to-guide-adjuvant-chemotherapy-decision-in-early-breast-cancer\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/genekor.com\/cs\/2025\/01\/28\/tumor-profiling-tests-to-guide-adjuvant-chemotherapy-decision-in-early-breast-cancer\/\"},\"author\":{\"name\":\"Ioanna Potska\",\"@id\":\"https:\/\/genekor.com\/cs\/#\/schema\/person\/d6c43cd4b4be66582d408967392cbcbd\"},\"headline\":\"Pou\u017eit\u00ed genomick\u00fdch test\u016f pro rozhodov\u00e1n\u00ed o adjuvantn\u00ed chemoterapii u \u010dasn\u00e9ho karcinomu prsu\",\"datePublished\":\"2025-01-28T11:19:04+00:00\",\"dateModified\":\"2025-02-12T12:16:33+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/genekor.com\/cs\/2025\/01\/28\/tumor-profiling-tests-to-guide-adjuvant-chemotherapy-decision-in-early-breast-cancer\/\"},\"wordCount\":442,\"publisher\":{\"@id\":\"https:\/\/genekor.com\/cs\/#organization\"},\"image\":{\"@id\":\"https:\/\/genekor.com\/cs\/2025\/01\/28\/tumor-profiling-tests-to-guide-adjuvant-chemotherapy-decision-in-early-breast-cancer\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/genekor.com\/wp-content\/uploads\/2025\/01\/logo-landscape-800x281-800x281-1.png\",\"articleSection\":[\"news\"],\"inLanguage\":\"cs\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/genekor.com\/cs\/2025\/01\/28\/tumor-profiling-tests-to-guide-adjuvant-chemotherapy-decision-in-early-breast-cancer\/\",\"url\":\"https:\/\/genekor.com\/cs\/2025\/01\/28\/tumor-profiling-tests-to-guide-adjuvant-chemotherapy-decision-in-early-breast-cancer\/\",\"name\":\"Pou\u017eit\u00ed genomick\u00fdch test\u016f pro rozhodov\u00e1n\u00ed o adjuvantn\u00ed chemoterapii u \u010dasn\u00e9ho karcinomu prsu - 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